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The genesis of this literature review was a desire to construct a list of progressive conditions that most would agree are not CP, to assist nonphysician field staff reviewing and abstracting medical and education records in a community setting as part of the Autism and Developmental Disabilities Monitoring Network. This Network is a multisite, collaborative program funded by the Centers for Disease Control and Prevention to monitor the occurrence of developmental disabilities, including CP, in 8-year-old children across the United States. White Mountain Fordham Wide Shaft RL73H
In this exploratory effort, our goal was to identify a list of brain disorders of childhood that by nature of their underlying pathophysiology and prognosis would not meet the nonprogressive component of the definition for CP. In this report, we present the methods for creating our list of progressive brain disorders of childhood and the table of such conditions identified to date.

Go to:

As our first goal, we developed criteria for progressive disorders to apply in our literature review ( Fergie Courtney Sandal 8zLYUf
). Since this activity was focused on a case definition for public health surveillance of CP, in particular for the Autism and Developmental Disabilities Monitoring Network, we concentrated on disorders with progressive features typically occurring by 8 years of age. Stanley Sequin Block Heel Mules mc7sgzCh
By definition, we did not consider conditions that are purely myopathies, disorders only involving the spinal cord, or peripheral neuropathies (neuromuscular disorders), since the primary pathology in these conditions is not in the brain. Progressive features were defined primarily by loss of motor skills or milestones, although descriptions of disorders often more broadly described generalized regression, deteriorating clinical courses or neuropathological findings, or normal early development with subsequent developmental delay. If a disorder was clearly a neurodegenerative condition, we decided to list it for the purposes of exclusion from surveillance, even if some of the neurologic findings progressed and others did not. Another important feature that we considered was childhood mortality; lethality alone was not a criterion for progressiveness, since some genetic conditions known for mortality due to malformations or pathophysiologic processes outside of the central nervous system can have static or even improving neurologic manifestations.

Public Health Surveillance Criteria for Progressive Brain Disorders of Childhood

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The criteria took into account what is typical or described in the majority of children with disorders in question. The rationale for this principle was our belief that when neurologic deterioration is a rare feature, typical children with certain diagnoses who might have CP-like features for reasons unrelated to the disorder should not be excluded categorically. In practice, a limitation of applying this principle was the inadequate precision of literature quantifying the occurrence of CP-like features in rare genetic conditions. The issue of the effects of available therapies on natural history also is problematic, including the spectrum of interventions from diet and medications to enzyme replacement and stem-cell transplantation. Unfortunately, with our routine surveillance procedures, without a special study it is typically difficult to ascertain variables such as treatment regimens and timing of therapies that might be important in assessing the adequacy of treatment and its relationship to the clinical outcome of a particular child. Baretraps Dianna 60Jyx
For our list of progressive disorders, we did not review the core disorders on the Recommended Uniform Screening Panel for newborns in the United States, HarleyDavidson Amherst yYrVWI
since the typical outcome for these conditions has changed because treatment is routinely instituted shortly after birth, thus preventing progressive features, eg, hypotonia and intellectual disability with congenital hypothyroidism. For other conditions with more potential variability in treatment in the general population, we did not consider the effects of such therapies on natural histories, eg, hematopoietic stemcell transplantation in Krabbe disease. The rapid progress expected in the diagnosis and treatment of progressive disorders, with concomitant changes in newborn screening panels as well as clinical practice, is another caveat for the need to continuously update surveillance practices.

» Sam Edelman Thora oSKx20z
» Currency outlook: Global trends continue to pressure US dollar

Posted by Roper Belt It gfOHPmhxE
on Mar 7, 2018, in Fixed Income

Time to read: 3 min

US dollar :

We expect the US dollar to continue to depreciate due to ongoing global economic growth and converging central bank policies. We have revised our 2018 US Federal Reserve rate hike call from two to three, in line with US bond pricing. While recent inflation strength has raised the possibility of four rate hikes, we believe that is unlikely without significant wage pressures. Globally, the growth trend is expected to be stronger relative to the US, meaning non-US central banks should shift away from their accommodative stances, especially the Bank of Japan (BOJ) and the European Central Bank. There may be a demand shift away from US investments as growth outperforms elsewhere. Such a development could also weigh on the US dollar.

Euro :

The euro is likely to continue appreciating, in our view. We believe we are in the nascent stages of a global inflation regime shift, transitioning from a world of disinflationary risk to one that is more balanced. We believe the resulting policy changes will support a weaker US dollar and continue to view pullbacks in the euro as consolidation within a longer-term trend higher.

Renminbi :

The USD/RMB exchange rate has appreciated since the beginning of 2018 as a result of a weaker US dollar, the conversion of US dollars into local currency by Chinese companies and macro fund trading activities. The move has been consistent with other currencies against the US dollar. Following the renewal of the $50,000 foreign exchange conversion quota in January, the continued strength of the renminbi suggests that companies and households had over-accumulated US dollars in recent years. China’s policy makers have already started to loosen regulations to allow more capital outflows, and if the renminbi strengthens further, we expect more outflow channels to be opened.

Japanese yen:

The yen started out strong in 2018 due to increased expectations of tighter BOJ monetary policy, repatriation flows and general US dollar weakness. A strong yen should have a dampening effect on Japanese inflation, which will likely not be welcomed by policy officials and could make achieving the BOJ’s 2% inflation target more difficult. We have already seen government officials verbally intervene to dampen further yen appreciation, and we expect those efforts to intensify. However, we remain positive on the yen over the longer term given our bearish view on the US dollar.

British pound sterling :

We continue to look for opportunities to move overweight sterling. The currency is likely to be volatile in the coming months as talks get underway concerning the future of trade and a transition deal with the European Union (EU). We believe the UK will either agree on a soft Brexit or decide to remain in the EU. With the economy unlikely to collapse regardless of the outcome, we continue to look for attractive entry points for sterling. We expect these to come about if Brexit discussions become contentious.

Canadian dollar:

We are currently neutral on the Canadian dollar. After rallying sharply at the beginning of the year, it has since lost all of its gains and then some. Economic data at the end of January disappointed as the Canada Consumer Price Index remained low. That, combined with the increase in Canada’s trade deficit, probably weakened the currency. In addition, oil prices have fallen from the highs in January.

Australian dollar :

With the Reserve Bank of Australia (RBA) holding rates steady as expected at its February meeting, we remain neutral on the Australian dollar. The RBA continues to forecast a gradual improvement in the economy, with inflation reaching its target range of 2% to 3% sometime in 2019. However, the RBA remains concerned about the lack of wage inflation and weak consumer spending and reiterated its commitment to remain patient with interest rates.

Indian rupee :

We are neutral on the Indian rupee. Going forward, we see downside risks to the currency from higher-than-expected inflation, higher oil prices and an increasing current account deficit. On the other hand, strong foreign direct investment inflows, sizable foreign exchange reserves and an improving growth outlook will likely continue to support the rupee at current levels.

1 Source: Bloomberg L.P., data from Jan. 1, 2018 through Feb. 28, 2018

2 Source: Bank of Japan, Feb. 21, 2017

3 Source: Reserve Bank of Australia, Feb. 21, 2017

Blog header image: Peter Cho/Shutterstock.com

The dollar value of foreign investments will be affected by changes in the exchange rates between the dollar and the currencies in which those investments are traded.

The Consumer Price Index (CPI) measures change in consumer prices. In Canada, this is calculated by Statistics Canada.

A trade deficit is an economic measure of international trade in which a country’s imports exceed its exports. Therefore, a trade deficit represents an outflow of domestic currency to foreign markets.

Tags: currency outlook

Ray Uy, CFA

Why We Say Gesundheit When Someone Sneezes

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Emily Upton 20 comments

Jack Rogers Taylor Suede 5SvK6
about the meaning of the word “gesundheit” and other sneeze etiquette around the world.

You are probably accustomed to hearing or saying “bless you” after someone sneezes. It’s simple sneeze etiquette, at least in English speaking countries. In Germany, it’s polite to say “gesundheit” after someone sneezes, which more or less means “health.” More specifically, it’s made up of the word gesund, which means healthy, and the suffix ­ –heit , which means –hood. Literally, “healthy-hood.”

Foreign words run rampant in the English language, so it should come as no surprise that gesundheit has worked its way in alongside its German relatives Kindergarten, doppelganger, poltergeist, and noodle. It’s believed that gesundheit entered the English language some time in the early 20 th century as Germans began to migrate to English-speaking countries such as the United States.

The word steadily gained in popularity from there, and in some parts of the English-speaking world these days, it’s almost as popular as “bless you.”

The attraction of gesundheit isn’t hard to miss. The English “bless you” has inherent religious connotations. Some today simply aren’t religious and so look for an alternative, while others have become more concerned about the political correctness of the words and phrases they use, and religion has always been a hot-button issue. Just as people are moving away from saying “Merry Christmas” in favour of “Happy Holidays,” being able to wish someone “health” rather than “blessings” is seen as more politically correct.

Wishing someone well after they sneeze is an old practice, and it is something that can be found in (almost) every corner of the world. While the actual origin of sneeze etiquette is a mystery, the most popular and most plausible theory is that people believed a sneeze was a prelude to illness, and that wishing them health or luck with what was to come was only polite.

Another popular theory is that a sneeze is “letting the demons in” which is the origin of the “bless you” response; it was supposed to guard the sneezer and responder from the Devil. However, neither of these theories is backed by much in the way of actual evidence, and we may never know why people started responding to sneezes in the ways that they do.

Whatever the case, the sneeze appears to have caused worry in many different cultures. Along with gesundheit and “bless you,” here are just a few examples of how people acknowledge another person’s sneeze around the world:

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